The Curse of Harrenhal
The curse of Harrenhal is pretty much justified. Numerous houses and individuals that have held have eventually faced tragic ends. Like House Qoherys wiped out by Harren The Red.
Last of the line of House Strong was also executed by Lord Cregan Stark. In the individuals Tywin Lannister being killed by his own son. Amory Lorch being fed to a bear are enough to justify why the curse is legit, and to be clear, there are many other tragic happenings that various other houses, and individuals that held Harrenhal have faced.
Harrenhal is definitely a living ghost town. It is currently held by House Baelish.